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Bglap
Gene Detail
Symbol

Name
ID
Bglap
bone gamma carboxyglutamate protein
MGI:88156
Synonyms
Bglap, Bglap1, bone Gla protein, mOC-A, OC, OG1, osteocalcin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr3:88383501-88384464 bp, - strand
From VEGA annotation of GRCm38

  964 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104130  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: BGLAP
Gene Tree: Bglap

Human
homologs
BGLAP, bone gamma-carboxyglutamate (gla) protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 632
neXtProt AC: NX_P02818

Human Synonyms: BGP, OC, OCN

Human Chr (Location): 1q22; chr1:156242160-156243332 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Genomic Mutations involving Bglap (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.
 
Interactions
Bglap interacts with 16 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process biomineral tissue development, cellular response to BMP stimulus, ...
Component cell projection, cytoplasm, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (147 records)
Data Summary: Results (123)    Tissues (54)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 43
Northern blot 8
RT-PCR 48
RNase protection 16
cDNA source data(6)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase bglap    NEW 
Molecular
reagents
All nucleic(20) Genomic(3) cDNA(11) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022060 (Evidence)
Ensembl Gene Model ENSMUSG00000074483 (Evidence)
Entrez Gene 12096 (Evidence)
UniGene 389459
Consensus CDS Project CCDS17474.1
International Mouse Phenotyping Consortium Status Bglap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022060 VEGA Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
transcript OTTMUST00000052378 VEGA | MGI Sequence Detail 440 Not Applicable 
polypeptide OTTMUSP00000024830 VEGA | MGI Sequence Detail 95 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(6 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10)
Protein-related
information
ResourceIDDescription
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR002384 Osteocalcin/matrix Gla protein
Protein Ontology PR:000030444 osteocalcin
References
(Earliest) J:8426 Celeste AJ, et al., Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90
(Latest) J:219364 Zhou ZQ, et al., Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. Hum Mol Genet. 2015 Mar 15;24(6):1764-73
All references(208)
Other
accession IDs
MGD-MRK-1550, MGD-MRK-1552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory