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Bglap Gene Detail
Summary
  • Symbol
    Bglap
  • Name
    bone gamma carboxyglutamate protein
  • Synonyms
    Bglap1, bone Gla protein, mOC-A, OC, OG1, osteocalcin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88156
    NCBI Gene: 12096
  • Gene Overview
    MyGene.info: BGLAP
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 3, 38.82 cM
  • Mapping Data
    16 experiments
Homology
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  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BGP, OC, OCN
  • Links
    NCBI Gene ID: 632
    neXtProt AC: NX_P02818
    UniProt: P02818

  • Chr Location
    1q22; chr1:156241962-156243332 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022060 VEGA Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
    transcript OTTMUST00000052378 VEGA | MGI Sequence Detail 440 Not Applicable  
    polypeptide OTTMUSP00000024830 VEGA | MGI Sequence Detail 95 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      5 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
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    • UniProt
      1 Sequence
    • InterPro Domains
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR002384 Osteocalcin/matrix Gla protein
    Molecular
    Reagents
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    • All nucleic 21
      Genomic 3
      cDNA 12
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-1550, MGD-MRK-1552
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 162
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:8426 Celeste AJ, et al., Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90
    • Latest
      J:256083 Yang T, et al., Pten regulates neural crest proliferation and differentiation during mouse craniofacial development. Dev Dyn. 2018 Feb;247(2):304-314

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory