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Bglap
Gene Detail
 Symbol
Name
ID
Bglap
bone gamma carboxyglutamate protein
MGI:88156
Synonyms Bglap, Bglap1, bone Gla protein, mOC-A, OC, OG1, osteocalcin
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr3:88383501-88384464 bp, - strand
From VEGA annotation of GRCm38

  964 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104130  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Bglap

Human
homologs
Human Homolog BGLAP, bone gamma-carboxyglutamate (gla) protein
NCBI Gene ID 632
neXtProt AC  NX_P02818
Human Synonyms  BGP, OC, OCN
Human Chr (Location)  1q22; chr1:156242160-156243332 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.
 
Interactions
Bglap interacts with 16 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biomineral tissue development, cellular response to BMP stimulus, ...
Component cell projection, cytoplasm, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (119)    Tissues (54)    Images (33)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 39
Northern blot 8
RT-PCR 48
RNase protection 16
cDNA source data(6)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(3) cDNA(11) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022060 (Evidence)
Ensembl Gene ModelENSMUSG00000074483 (Evidence)
Entrez Gene12096 (Evidence)
UniGene389459
Consensus CDS ProjectCCDS17474.1
International Mouse Knockout Project StatusBglap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022060 VEGA Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
transcript OTTMUST00000052378 VEGA | MGI Sequence Detail 440 Not Applicable 
polypeptide OTTMUSP00000024830 VEGA | MGI Sequence Detail 95 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(6 from dbSNP Build 137)    SNPs within 2kb including multiple locations(10)
Protein-related
information
ResourceIDDescription
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR002384 Osteocalcin/matrix Gla protein
Protein Ontology PR:000030444 osteocalcin
References (Earliest) J:8426 Celeste AJ, et al., Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90
(Latest) J:209589 Wei J, et al., Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr 1;124(4):1-13
All references(197)
Other
accession IDs
MGD-MRK-1550, MGD-MRK-1552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory