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Bglap Gene Detail
Summary
  • Symbol
    Bglap
  • Name
    bone gamma carboxyglutamate protein
  • Synonyms
    Bglap, Bglap1, bone Gla protein, mOC-A, OC, OG1, osteocalcin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88156
    NCBI Gene: 12096
  • Gene Overview
    MyGene.info: BGLAP
Location & Maps
more
Homology
more
  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BGLAP, bone gamma-carboxyglutamate protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BGP, OC, OCN
  • Links
    NCBI Gene ID: 632
    neXtProt AC: NX_P02818

  • Chr Location
    1q22; chr1:156242160-156243332 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Bglap
  • Incidental Mutations
Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022060 VEGA Gene Model | MGI Sequence Detail 964 C57BL/6J ±  kb
transcript OTTMUST00000052378 VEGA | MGI Sequence Detail 440 Not Applicable  
polypeptide OTTMUSP00000024830 VEGA | MGI Sequence Detail 95 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR002384 Osteocalcin/matrix Gla protein
Molecular
Reagents
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  • All nucleic 20
    Genomic 3
    cDNA 11
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1550, MGD-MRK-1552
References
more
  • Summaries
    All 209
    Developmental Gene Expression 149
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:8426 Celeste AJ, et al., Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90
  • Latest
    J:223511 Wei J, et al., Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015 Jun 18;161(7):1576-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory