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Atp2b4
Gene Detail
 Symbol
Name
ID
Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
MGI:88111
Synonyms PMCA4
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:133702678-133801041 bp, - strand
From VEGA annotation of GRCm38

  98364 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b4

Human
homologs
Human Homolog ATP2B4, ATPase, Ca++ transporting, plasma membrane 4
NCBI Gene ID 493
neXtProt AC  NX_P23634
Human Synonyms  ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Human Chr (Location)  1q32.1; chr1:203626787-203744081 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(4) Gene trapped(4)
 
Homozygous null mice display male infertility with impaired sperm motility.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process ATP catabolic process, calcium ion export, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function ATP binding, calcium-transporting ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (127)    Tissues (97)    Images (23)
Theiler Stages: 15, 22, 23
Assay TypeResults
RNA in situ 122
Western blot 5
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016442 (Evidence)
Ensembl Gene ModelENSMUSG00000026463 (Evidence)
Entrez Gene381290 (Evidence)
UniGene188617
DFCITC1649119, TC1674234, TC1690327
DoTSDT.101368752, DT.40142197, DT.87028127, DT.94130139
NIA Mouse Gene IndexU134130
Consensus CDS ProjectCCDS15298.1, CCDS48365.1
International Mouse Knockout Project StatusAtp2b4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016442 VEGA Gene Model | MGI Sequence Detail 98364 C57BL/6J ±  kb
transcript OTTMUST00000039594 VEGA | MGI Sequence Detail 8504 Not Applicable 
polypeptide OTTMUSP00000017683 VEGA | MGI Sequence Detail 1205 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(16) UniProt(9)
Polymorphisms SNPs within 2kb(533 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
InterPro IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004448 plasma membrane calcium-transporting ATPase 4
References (Earliest) J:16146 Hunter KW, et al., Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1. Genomics. 1993 Dec;18(3):510-9
(Latest) J:202053 Patel R, et al., Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation. Biol Reprod. 2013;89(1):6
All references(49)
Other
accession IDs
MGD-MRK-1464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory