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Atp2b4
Gene Detail
Symbol

Name
ID
Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
MGI:88111
Synonyms
PMCA4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:133699457-133801041 bp, - strand
From VEGA annotation of GRCm38

  101585 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP2B4
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b4

Human
homologs
ATP2B4, ATPase, Ca++ transporting, plasma membrane 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 493
neXtProt AC: NX_P23634

Human Synonyms: ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x

Human Chr (Location): 1q32.1; chr1:203626787-203744081 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display male infertility with impaired sperm motility.
 
Phenotype Images(2)
Interactions
Atp2b4 interacts with 451 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (127)    Tissues (97)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 122
Western blot 5
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atp2b2 ; ZFIN atp2b4    NEW 
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016442 (Evidence)
Ensembl Gene Model ENSMUSG00000026463 (Evidence)
Entrez Gene 381290 (Evidence)
UniGene 188617
DFCI TC1649119, TC1674234, TC1690327
DoTS DT.101368752, DT.40142197, DT.87028127, DT.94130139
NIA Mouse Gene Index U134130
EC 3.6.3.8
Consensus CDS Project CCDS15298.1, CCDS48365.1
International Mouse Phenotyping Consortium Status Atp2b4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016442 VEGA Gene Model | MGI Sequence Detail 101585 C57BL/6J ±  kb
transcript OTTMUST00000039594 VEGA | MGI Sequence Detail 11725 Not Applicable 
polypeptide OTTMUSP00000017683 VEGA | MGI Sequence Detail 1205 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(18) UniProt(10)
Polymorphisms
SNPs within 2kb(541 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
InterPro IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
Protein Ontology PR:000004448 plasma membrane calcium-transporting ATPase 4
References
(Earliest) J:16146 Hunter KW, et al., Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1. Genomics. 1993 Dec;18(3):510-9
(Latest) J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510
All references(51)
Other
accession IDs
MGD-MRK-1464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory