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Atp2b4 Gene Detail
Summary
  • Symbol
    Atp2b4
  • Name
    ATPase, Ca++ transporting, plasma membrane 4
  • Synonyms
    PMCA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88111
    NCBI Gene: 381290
  • Gene Overview
    MyGene.info: ATP2B4
Location & Maps
more
  • Sequence Map
    Chr1:133699457-133801041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101585 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATP2B4, ATPase plasma membrane Ca2+ transporting 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP2B4, ATPase plasma membrane Ca2+ transporting 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
  • Links
    NCBI Gene ID: 493
    neXtProt AC: NX_P23634

  • Chr Location
    1q32.1; chr1:203626787-203744081 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Atp2b4
  • Incidental Mutations
Homozygous null mice display male infertility with impaired sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016442 VEGA Gene Model | MGI Sequence Detail 101585 C57BL/6J ±  kb
transcript OTTMUST00000039594 VEGA | MGI Sequence Detail 11725 Not Applicable  
polypeptide OTTMUSP00000017683 VEGA | MGI Sequence Detail 1205 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    538 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004448 plasma membrane calcium-transporting ATPase 4
  • EC
  • InterPro Domains
    IPR006068 Cation-transporting P-type ATPase, C-terminal
    IPR004014 Cation-transporting P-type ATPase, N-terminal
    IPR023214 HAD-like domain
    IPR030319 Plasma membrane calcium-transporting ATPase 1/4
    IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
    IPR001757 P-type ATPase
    IPR008250 P-type ATPase, A domain
    IPR023299 P-type ATPase, cytoplasmic domain N
    IPR018303 P-type ATPase, phosphorylation site
    IPR006408 P-type ATPase, subfamily IIB
    IPR023298 P-type ATPase, transmembrane domain
Molecular
Reagents
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  • All nucleic 43
    cDNA 43

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1464
References
more
  • Summaries
    All 51
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:16146 Hunter KW, et al., Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1. Genomics. 1993 Dec;18(3):510-9
  • Latest
    J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory