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Asl Gene Detail
Summary
  • Symbol
    Asl
  • Name
    argininosuccinate lyase
  • Synonyms
    2510006M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88084
    NCBI Gene: 109900
Location & Maps
more
  • Sequence Map
    Chr5:130011258-130029247 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17990 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ASL, argininosuccinate lyase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ASL, argininosuccinate lyase
    Orthology source: HomoloGene
  • Synonyms
    ASAL
  • Links
    NCBI Gene ID: 435
    neXtProt AC: NX_P04424

  • Chr Location
    7q11.21; chr7:66075789-66093343 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Asl mouse models; 1 with human ASL associations

Human Disease Mouse Models
       Argininosuccinic Aciduria   OMIM: 207900 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Asl
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene fed well initially but then stopped feeding and became inactive before dying within 48 hours of birth. Arginine metabolism is disrupted leading to abnormal circulating amino acid levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033763 VEGA Gene Model | MGI Sequence Detail 17990 C57BL/6J ±  kb
transcript OTTMUST00000085072 VEGA | MGI Sequence Detail 1824 Not Applicable  
polypeptide OTTMUSP00000045917 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 112
    cDNA 111
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1420, MGI:1924052
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:18110 Lalley PA, et al., Gene assignment of argininosuccinate lyase to mouse chromosome 5. Cytogenet Cell Genet. 1979;25:178 (Abstr.)
  • Latest
    J:221843 Premkumar MH, et al., Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G347-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory