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Asl Gene Detail
Summary
  • Symbol
    Asl
  • Name
    argininosuccinate lyase
  • Synonyms
    2510006M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88084
    NCBI Gene: 109900
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:130011258-130029247 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17990 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 68.37 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ASL, argininosuccinate lyase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ASL, argininosuccinate lyase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASAL
  • Links
    NCBI Gene ID: 435
    neXtProt AC: NX_P04424
    UniProt: P04424

  • Chr Location
    7q11.21; chr7:66075789-66093343 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Asl mouse models; 1 with human ASL associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene fed well initially but then stopped feeding and became inactive before dying within 48 hours of birth. Arginine metabolism is disrupted leading to abnormal circulating amino acid levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033763 VEGA Gene Model | MGI Sequence Detail 17990 C57BL/6J ±  kb
    transcript OTTMUST00000085072 VEGA | MGI Sequence Detail 1824 Not Applicable  
    polypeptide OTTMUSP00000045917 VEGA | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      121 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 112
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1420, MGI:1924052
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:221843 Premkumar MH, et al., Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G347-54

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory