About   Help   FAQ
Asl
Gene Detail
Symbol

Name
ID
Asl
argininosuccinate lyase
MGI:88084
Synonyms
2510006M18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
68.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:130011258-130025132 bp, - strand
From VEGA annotation of GRCm38

  13875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ASL
Protein SuperFamily: argininosuccinate lyase
Gene Tree: Asl

Human
homologs
ASL, argininosuccinate lyase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 435
neXtProt AC: NX_P04424

Human Synonyms: ASAL

Human Chr (Location): 7q11.21; chr7:66075789-66093343 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ASL

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene fed well initially but then stopped feeding and became inactive before dying within 48 hours of birth. Arginine metabolism is disrupted leading to abnormal circulating amino acid levels.
 
Human Diseases Modeled in Mice Using Asl (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Asl interacts with 45 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process ammonia assimilation cycle, arginine biosynthetic process, ...
Component cell body fiber, cytoplasm, ...
Function argininosuccinate lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (96)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
Northern blot 10
cDNA source data(109)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ASL1 ; Xenbase asl ; ZFIN asl    NEW 
Molecular
reagents
All nucleic(112) cDNA(111) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033763 (Evidence)
Ensembl Gene Model ENSMUSG00000025533 (Evidence)
Entrez Gene 109900 (Evidence)
UniGene 23869
DFCI TC1584095, TC1624525, TC1674201
DoTS DT.533138, DT.94277656, DT.94277677
NIA Mouse Gene Index U026769
EC 4.3.2.1
Consensus CDS Project CCDS51655.1
International Mouse Phenotyping Consortium Status Asl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033763 VEGA Gene Model | MGI Sequence Detail 13875 C57BL/6J ±  kb
transcript OTTMUST00000085072 VEGA | MGI Sequence Detail 1824 Not Applicable 
polypeptide OTTMUSP00000045917 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(4) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009049 Argininosuccinate lyase
InterPro IPR024083 Fumarase/histidase, N-terminal
InterPro IPR000362 Fumarate lyase
InterPro IPR020557 Fumarate lyase, conserved site
InterPro IPR022761 Fumarate lyase, N-terminal
InterPro IPR008948 L-Aspartase-like
Protein Ontology PR:000004373 argininosuccinate lyase
References
(Earliest) J:18110 Lalley PA, et al., Gene assignment of argininosuccinate lyase to mouse chromosome 5. Cytogenet Cell Genet. 1979;25:178 (Abstr.)
(Latest) J:196817 Nagamani SC, et al., Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet. 2012 May 4;90(5):836-46
All references(42)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1420, MGI:1924052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory