About   Help   FAQ
Arg1
Gene Detail
Symbol

Name
ID
Arg1
arginase, liver
MGI:88070
Synonyms
AI, Arg-1, PGIF
Feature Type
protein coding gene
Genetic Map
Chromosome 10
12.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:24915208-24927470 bp, - strand
From Ensembl annotation of GRCm38

  12263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:29  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ARG1
Protein SuperFamily: ureohydrolase/formiminoglutamase/proclavaminate amidino hydrolase
Gene Tree: Arg1

Human
homologs
ARG1, arginase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 383
neXtProt AC: NX_P05089

Human Chr (Location): 6q23; chr6:131573203-131584332 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, and increased macrophage nitric oxide production.
 
Human Diseases Modeled in Mice Using Arg1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Arg1 interacts with 88 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process arginine catabolic process to ornithine, arginine metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function arginase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (491)    Tissues (316)    Images (122)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 445
RT-PCR 46
cDNA source data(165)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arg1 ; ZFIN arg1    NEW 
Molecular
reagents
All nucleic(167) cDNA(165) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019987 (Evidence)
Entrez Gene 11846 (Evidence)
UniGene 154144
DFCI TC1574794
DoTS DT.101407775, DT.536348
NIA Mouse Gene Index U031620
EC 3.5.3.1
Consensus CDS Project CCDS48523.1
International Mouse Phenotyping Consortium Status Arg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019987 Ensembl Gene Model | MGI Sequence Detail 12263 C57BL/6J ±  kb
transcript ENSMUST00000020161 Ensembl | MGI Sequence Detail 1476 Not Applicable 
polypeptide ENSMUSP00000020161 Ensembl | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014033 Arginase
InterPro IPR006035 Ureohydrolase
InterPro IPR023696 Ureohydrolase domain
InterPro IPR020855 Ureohydrolase, manganese-binding site
Protein Ontology PR:000001844 arginase-1
References
(Earliest) J:15675 Ohtake A, et al., Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1064-70
(Latest) J:217115 Colegio OR, et al., Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014 Sep 25;513(7519):559-63
All references(78)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1392, MGD-MRK-1393, MGI:2143548

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory