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Arg1 Gene Detail
Summary
  • Symbol
    Arg1
  • Name
    arginase, liver
  • Synonyms
    AI, Arg-1, PGIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:88070
    NCBI Gene: 11846
  • Gene Overview
    MyGene.info: ARG1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24915207-24927470 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88070
protein coding gene Chr10:24915207-24927484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017096
protein coding gene Chr10:22913588-22927899 (-)
A/J MGP_AJ_G0017073
protein coding gene Chr10:22237155-22248686 (-)
AKR/J MGP_AKRJ_G0017033
protein coding gene Chr10:22612988-22624540 (-)
BALB/cJ MGP_BALBcJ_G0017036
protein coding gene Chr10:22335026-22348993 (-)
C3H/HeJ MGP_C3HHeJ_G0016856
protein coding gene Chr10:22821472-22833279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017494
protein coding gene Chr10:23618173-23632185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015192
protein coding gene Chr10:20929653-20941461 (-)
CAST/EiJ MGP_CASTEiJ_G0016435
protein coding gene Chr10:22754079-22767328 (-)
CBA/J MGP_CBAJ_G0016830
protein coding gene Chr10:24690896-24706317 (-)
DBA/2J MGP_DBA2J_G0016935
protein coding gene Chr10:21967622-21980085 (-)
FVB/NJ MGP_FVBNJ_G0016930
protein coding gene Chr10:21667359-21679588 (-)
LP/J MGP_LPJ_G0017012
protein coding gene Chr10:22906422-22917863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016960
protein coding gene Chr10:24799816-24812350 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017530
protein coding gene Chr10:22464342-22477159 (-)
PWK/PhJ MGP_PWKPhJ_G0016217
protein coding gene Chr10:21754708-21767859 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016001
protein coding gene Chr10:22301070-22312797 (-)
WSB/EiJ MGP_WSBEiJ_G0016498
protein coding gene Chr10:22597547-22609077 (-)



Homology
more
  • Human Ortholog
    ARG1, arginase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARG1, arginase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 383
    neXtProt AC: NX_P05089
    UniProt: P05089

  • Chr Location
    6q23.2; chr6:131573159-131584332 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arg1 mouse models; 1 with human ARG1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 6 genetic backgrounds
    29 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, andincreased macrophage nitric oxide production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11846 NCBI Gene Model | MGI Sequence Detail 12264 C57BL/6J ±  kb
    transcript NM_007482 RefSeq | MGI Sequence Detail 1489 C57BL/6  
    polypeptide Q61176 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 170
      cDNA 167
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1392, MGD-MRK-1393, MGI:2143548
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 8
      Phenotypes 61
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265518 Schneider C, et al., A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 Jul 12;174(2):271-284.e14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory