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Arg1
Gene Detail
Symbol

Name
ID
Arg1
arginase, liver
MGI:88070
Synonyms
AI, Arg-1, PGIF
Feature Type
protein coding gene
Genetic Map
Chromosome 10
12.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:24915208-24927470 bp, - strand
From Ensembl annotation of GRCm38

  12263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:29  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ureohydrolase/formiminoglutamase/proclavaminate amidino hydrolase
Gene Tree: Arg1

Human
homologs
Human Homolog ARG1, arginase 1
NCBI Gene ID 383
neXtProt AC  NX_P05089
Human Chr (Location)  6q23; chr6:131573204-131584332 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, and increased macrophage nitric oxide production.
 
Human Diseases Modeled Using Mouse Arg1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Arg1 interacts with 88 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process arginine catabolic process to ornithine, arginine metabolic process, ...
Component cytoplasm, extracellular space, ...
Function arginase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (491)    Tissues (316)    Images (122)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 445
RT-PCR 46
cDNA source data(165)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(167) cDNA(165) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000019987 (Evidence)
Entrez Gene11846 (Evidence)
UniGene154144
DFCITC1574794
DoTSDT.101407775, DT.536348
NIA Mouse Gene IndexU031620
EC3.5.3.1
Consensus CDS ProjectCCDS48523.1
International Mouse Knockout Project StatusArg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019987 Ensembl Gene Model | MGI Sequence Detail 12263 C57BL/6J ±  kb
transcript ENSMUST00000020161 Ensembl | MGI Sequence Detail 1476 Not Applicable 
polypeptide ENSMUSP00000020161 Ensembl | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014033 Arginase
InterPro IPR006035 Ureohydrolase
InterPro IPR023696 Ureohydrolase domain
InterPro IPR020855 Ureohydrolase, manganese-binding site
Protein Ontology PR:000001844 arginase-1
References
(Earliest) J:15675 Ohtake A, et al., Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1064-70
(Latest) J:212330 Wijnands KA, et al., Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia. PLoS One. 2014;9(1):e86135
All references(76)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1392, MGD-MRK-1393, MGI:2143548

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory