Arg1
Gene Detail

Symbol Name ID

Arg1 arginase, liver MGI:88070

Synonyms

AI, Arg-1, PGIF

Feature Type

protein coding gene

Genetic Map

Chromosome 10

12.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:24915208-24927470 bp, - strand From Ensembl annotation of GRCm38   12263 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:29  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: ureohydrolase/formiminoglutamase/proclavaminate amidino hydrolase
Gene Tree: Arg1

Human homologs

Human Homolog		ARG1, arginase, liver
NCBI Gene ID		383
neXtProt AC		NX_P05089
Human Chr (Location)		6q23; chr6:131894344-131905472 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ARG1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, and increased macrophage nitric oxide production.

 
Human Diseases Modeled Using Mouse Arg1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	arginine catabolic process to ornithine, arginine metabolic process, ...
Component	cytoplasm, extracellular space, ...
Function	arginase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (309)    Tissues (178)    Images (74)
Theiler Stages: 11, 13, 19, 22, 23, 28

Assay Type	Results
RNA in situ	263
RT-PCR	46

cDNA source data(163)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(165) cDNA(163) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000019987 (Evidence)
Entrez Gene	11846 (Evidence)
UniGene	154144
DFCI	TC1574794
DoTS	DT.101407775, DT.536348
NIA Mouse Gene Index	U031620
EC	3.5.3.1
Consensus CDS Project	CCDS48523.1
International Mouse Knockout Project Status	Arg1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000019987	Ensembl Gene Model | MGI Sequence Detail	12263	C57BL/6J
transcript	ENSMUST00000020161	Ensembl | MGI Sequence Detail	1476	Not Applicable
polypeptide	ENSMUSP00000020161	Ensembl | MGI Sequence Detail	323	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014033	Arginase
InterPro	IPR006035	Ureohydrolase
InterPro	IPR023696	Ureohydrolase domain
InterPro	IPR020855	Ureohydrolase, manganese-binding site
Protein Ontology	PR:000001844	arginase-1

References

(Earliest) J:15675 Ohtake A, et al., Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1064-70
(Latest) J:195065 Chang J, et al., Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur J Immunol. 2013 Apr;43(4):967-78
All references(61)

Other accession IDs

MGD-MRK-1392, MGD-MRK-1393, MGI:2143548