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Arg1 Gene Detail
Summary
  • Symbol
    Arg1
  • Name
    arginase, liver
  • Synonyms
    AI, Arg-1, PGIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:88070
    NCBI Gene: 11846
Location & Maps
more
  • Sequence Map
    Chr10:24915208-24927470 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12263 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARG1, arginase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARG1, arginase 1
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 383
    neXtProt AC: NX_P05089

  • Chr Location
    6q23; chr6:131573203-131584332 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Arg1 mouse models; 1 with human ARG1 associations

Human Disease Mouse Models
       Argininemia   OMIM: 207800 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 6 genetic backgrounds
    27 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Arg1
  • Incidental Mutations
Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, andincreased macrophage nitric oxide production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019987 Ensembl Gene Model | MGI Sequence Detail 12263 C57BL/6J ±  kb
transcript ENSMUST00000020161 Ensembl | MGI Sequence Detail 1476 Not Applicable  
polypeptide ENSMUSP00000020161 Ensembl | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    232 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 167
    cDNA 165
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1392, MGD-MRK-1393, MGI:2143548
References
more
  • Summaries
    All 79
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 5
    Phenotypes 45
  • Earliest
    J:15675 Ohtake A, et al., Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1064-70
  • Latest
    J:227049 Hunt JB Jr, et al., Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. J Neurosci. 2015 Nov 4;35(44):14842-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory