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Areg
Gene Detail
 Symbol
Name
ID
Areg
amphiregulin
MGI:88068
Synonyms AR, Sdgf
Feature Type protein coding gene
Genetic Map
Chromosome 5
44.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:91139615-91148432 bp, + strand
From NCBI annotation of GRCm38

  8818 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: amphiregulin
Gene Tree: Areg

Human
homologs
Human Homolog AREG, amphiregulin
NCBI Gene ID 374
neXtProt AC  NX_P15514
Human Synonyms  AR, AREGB, CRDGF, SDGF
Human Chr (Location)  4q13.3; chr4:74445136-74455009 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds.
 
Interactions
Areg interacts with 61 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis, epidermal growth factor receptor signaling pathway, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (16)    Tissues (11)    Images (3)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RT-PCR 16
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029378 (Evidence)
Entrez Gene11839 (Evidence)
UniGene8039
DFCITC1587328
DoTSDT.40167233
NIA Mouse Gene IndexU005794
Consensus CDS ProjectCCDS19421.1
International Mouse Knockout Project StatusAreg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11839 NCBI Gene Model | MGI Sequence Detail 8818 C57BL/6J ±  kb
transcript NM_009704 RefSeq | MGI Sequence Detail 1199 C57BL/6 
polypeptide P31955 UniProt | EBI | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015497 Epidermal growth factor receptor ligand
Protein Ontology PR:000004200 amphiregulin
Graphical View of Protein Domain Structure
References (Earliest) J:27351 Sonoda H, et al., Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line. Biochem Biophys Res Commun. 1992 May 29;185(1):103-9
(Latest) J:208293 Chen J, et al., Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 Dec;15(12):1415-23
All references(67)
Other
accession IDs
MGD-MRK-1388, MGD-MRK-16238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory