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Areg Gene Detail
Summary
  • Symbol
    Areg
  • Name
    amphiregulin
  • Synonyms
    AR, Mcub, Sdgf
  • Feature Type
    protein coding gene
  • IDs
    MGI:88068
    NCBI Gene: 11839
Location & Maps
more
  • Sequence Map
    Chr5:91139599-91148432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8834 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AREG, amphiregulin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AREG, amphiregulin
    Orthology source: HomoloGene
  • Synonyms
    AR, AREGB, CRDGF, SDGF
  • Links
    NCBI Gene ID: 374
    neXtProt AC: NX_P15514

  • Chr Location
    4q13.3; chr4:74445098-74455009 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    5
  • Genomic Mutations
    4 involving Areg
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055520 VEGA Gene Model | MGI Sequence Detail 8834 C57BL/6J ±  kb
transcript OTTMUST00000137420 VEGA | MGI Sequence Detail 1215 Not Applicable  
polypeptide OTTMUSP00000072375 VEGA | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR015497 Epidermal growth factor receptor ligand
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 9
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1388, MGD-MRK-16238, MGI:1890801
References
more
  • Summaries
    All 71
    Developmental Gene Expression 15
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:27351 Sonoda H, et al., Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line. Biochem Biophys Res Commun. 1992 May 29;185(1):103-9
  • Latest
    J:226559 Monticelli LA, et al., IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10762-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory