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Areg
Gene Detail
Symbol

Name
ID
Areg
amphiregulin
MGI:88068
Synonyms
AR, Mcub, Sdgf
Feature Type
protein coding gene
Genetic Map
Chromosome 5
44.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:91139615-91148432 bp, + strand
From NCBI annotation of GRCm38

  8818 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AREG
Protein SuperFamily: amphiregulin
Gene Tree: Areg

Human
homologs
AREG, amphiregulin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 374
neXtProt AC: NX_P15514

Human Synonyms: AR, AREGB, CRDGF, SDGF

Human Chr (Location): 4q13.3; chr4:74445098-74455009 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds.
 
Interactions
Areg interacts with 61 markers (Mir17, Mir20a, Mir20b, ...)
Expression
Literature Summary: (15 records)
Data Summary: Results (16)    Tissues (11)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 16
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(9) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029378 (Evidence)
Entrez Gene 11839 (Evidence)
UniGene 8039
DFCI TC1587328
DoTS DT.40167233
NIA Mouse Gene Index U005794
Consensus CDS Project CCDS19421.1
International Mouse Phenotyping Consortium Status Areg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11839 NCBI Gene Model | MGI Sequence Detail 8818 C57BL/6J ±  kb
transcript NM_009704 RefSeq | MGI Sequence Detail 1199 C57BL/6 
polypeptide P31955 UniProt | EBI | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015497 Epidermal growth factor receptor ligand
Protein Ontology PR:000004200 amphiregulin
Graphical View of Protein Domain Structure
References
(Earliest) J:27351 Sonoda H, et al., Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line. Biochem Biophys Res Commun. 1992 May 29;185(1):103-9
(Latest) J:217394 Siggs OM, et al., Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice. Biol Open. 2014;3(12):1151-7
All references(72)
Other
accession IDs
MGD-MRK-1388, MGD-MRK-16238, MGI:1890801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory