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Areg Gene Detail
Summary
  • Symbol
    Areg
  • Name
    amphiregulin
  • Synonyms
    AR, Mcub, Sdgf
  • Feature Type
    protein coding gene
  • IDs
    MGI:88068
    NCBI Gene: 11839
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr5:91287458-91296291 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88068
 protein coding gene Chr5:91287458-91296291 (+)
129S1/SvImJ ENSMUSG00200007210
 protein coding gene Chr5:87014808-87023630 (+)
A/J ENSMUSG00195024682
 protein coding gene Chr5:86188456-86197289 (+)
AKR/J ENSMUSG00220011347
 protein coding gene Chr5:86312888-86321708 (+)
BALB/cJ ENSMUSG00180020241
 protein coding gene Chr5:86026834-86035655 (+)
C3H/HeJ ENSMUSG00175042553
 protein coding gene Chr5:88122427-88131247 (+)
C57BL/6NJ ENSMUSG00215018438
 protein coding gene Chr5:86887581-86896414 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027402
 protein coding gene Chr5:84278625-84287312 (+)
CAST/EiJ ENSTCUG00005036445
 protein coding gene Chr5:85775185-85784050 (+)
CBA/J ENSMUSG00210005742
 protein coding gene Chr5:86922206-86931026 (+)
DBA/2J ENSMUSG00185037934
 protein coding gene Chr5:88843161-88851981 (+)
FVB/NJ ENSMUSG00205023548
 protein coding gene Chr5:85737487-85746307 (+)
JF1/MsJ ENSUMUG00000035988
 protein coding gene Chr5:93129319-93138234 (+)
LP/J ENSMUSG00230023570
 protein coding gene Chr5:93541148-93549970 (+)
NOD/ShiLtJ ENSMUSG00190029232
 protein coding gene Chr5:85804688-85813506 (+)
NZO/HlLtJ ENSMUSG00225008778
 protein coding gene Chr5:98688647-98697469 (+)
PWK/PhJ ENSLUMG00010027029
 protein coding gene Chr5:85802027-85810955 (+)
SPRET/EiJ ENSMSPG00010034272
 protein coding gene Chr5:88183990-88191238 (+)
WSB/EiJ ENSIUOG00005029069
 protein coding gene Chr5:88815049-88823890 (+)



Homology
more
  • Human Ortholog
    AREG, amphiregulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AREG, amphiregulin
  • Synonyms
    AR, AREGB, CRDGF, SDGF
  • Links
    NCBI Gene ID: 374
    UniProt: P15514

  • Chr Location
    4q13.3; chr4:74444999-74455005 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AREG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    9
  • Radiation induced
    1
  • Spontaneous
    2
  • Targeted
    7
  • Genomic Mutations
    4 involving Areg
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    33 strains or lines available
Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    60
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    19
  • cDNA Data
    9
  • Literature Summary
    29
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11839 NCBI Gene Model | MGI Sequence Detail 8834 C57BL/6J ±  kb
transcript NM_009704 RefSeq | MGI Sequence Detail 1215 ZRU/MplStud  
polypeptide P31955 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 10
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1388, MGD-MRK-16238, MGI:1890801
References
more
  • Summaries
    All 230
    Developmental Gene Expression 29
    Gene Ontology 14
    Phenotypes 84
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:391810 Lv J, et al., Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m(6)A-dependent Areg signaling. Int J Biol Sci. 2026;22(12):6465-6482
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory