About   Help   FAQ
Areg Gene Detail
Summary
  • Symbol
    Areg
  • Name
    amphiregulin
  • Synonyms
    AR, Mcub, Sdgf
  • Feature Type
    protein coding gene
  • IDs
    MGI:88068
    NCBI Gene: 11839
  • Gene Overview
    MyGene.info: AREG
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91139599-91148432 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88068
protein coding gene Chr5:91139599-91148432 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029736
protein coding gene Chr5:92217837-92226659 (+)
A/J MGP_AJ_G0029702
protein coding gene Chr5:88601985-88610818 (+)
AKR/J MGP_AKRJ_G0029648
protein coding gene Chr5:91470655-91479474 (+)
BALB/cJ MGP_BALBcJ_G0029712
protein coding gene Chr5:89480243-89489063 (+)
C3H/HeJ MGP_C3HHeJ_G0029435
protein coding gene Chr5:91874662-91883482 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030166
protein coding gene Chr5:95916245-95925078 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027402
protein coding gene Chr5:84278625-84287312 (+)
CAST/EiJ MGP_CASTEiJ_G0028845
protein coding gene Chr5:91255772-91286831 (+)
CBA/J MGP_CBAJ_G0029405
protein coding gene Chr5:99187227-99196047 (+)
DBA/2J MGP_DBA2J_G0029549
protein coding gene Chr5:88658770-88667590 (+)
FVB/NJ MGP_FVBNJ_G0029508
protein coding gene Chr5:87504213-87513033 (+)
LP/J MGP_LPJ_G0029637
protein coding gene Chr5:92610376-92619198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029537
protein coding gene Chr5:104162976-104171795 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030200
protein coding gene Chr5:91013177-91021999 (+)
PWK/PhJ MGP_PWKPhJ_G0028564
protein coding gene Chr5:87721800-87731073 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028399
protein coding gene Chr5:90397325-90406281 (+)
WSB/EiJ MGP_WSBEiJ_G0028924
protein coding gene Chr5:91461844-91470685 (+)



Homology
more
  • Human Ortholog
    AREG, amphiregulin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AREG, amphiregulin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AR, AREGB, CRDGF, SDGF
  • Links
    NCBI Gene ID: 374
    neXtProt AC: NX_P15514
    UniProt: P15514

  • Chr Location
    4q13.3; chr4:74445098-74455009 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired development of mammary gland ducts in pubescent females. Mutant ducts show retarded elongation with few terminal end buds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11839 NCBI Gene Model | MGI Sequence Detail 8834 C57BL/6J ±  kb
    transcript NM_009704 RefSeq | MGI Sequence Detail 1215 C57BL/6  
    polypeptide P31955 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 10
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1388, MGD-MRK-16238, MGI:1890801
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 23
      Gene Ontology 9
      Phenotypes 43
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265518 Schneider C, et al., A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 Jul 12;174(2):271-284.e14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory