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Apoe
Gene Detail
Symbol

Name
ID
Apoe
apolipoprotein E
MGI:88057
STS
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr7:19696109-19699166 bp, - strand
From VEGA annotation of GRCm38

  3058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: APOE
Gene Tree: Apoe

Human
homologs
APOE, apolipoprotein E
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 348
neXtProt AC: NX_P02649

Human Synonyms: AD2, APO-E, LDLCQ5, LPG

Human Chr (Location): 19q13.2; chr19:44905749-44909395 (+)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human APOE

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(19) Spontaneous(1) Targeted(20) Transgenic(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
 
Human Diseases Modeled in Mice Using Apoe (1)    Mutations Annotated to Human Diseases (5)    Phenotype Images(13)
Interactions
Apoe interacts with 57 markers (Mir1a-1, Mir1a-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (170 annotations)
Process aging, AMPA glutamate receptor clustering, ...
Component blood microparticle, cell, ...
Function antioxidant activity, beta-amyloid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (249)    Tissues (171)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 169
Northern blot 30
RT-PCR 50
cDNA source data(1787)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apoe ; ZFIN apoea, apoeb    NEW 
Molecular
reagents
All nucleic(1799) Genomic(2) cDNA(1787) Primer pair(4) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000038239 (Evidence)
Ensembl Gene Model ENSMUSG00000002985 (Evidence)
Entrez Gene 11816 (Evidence)
UniGene 305152
DFCI TC1573648, TC1687215
DoTS DT.101365789, DT.87073740, DT.91406850, DT.91569392, DT.94158372, DT.94158395, DT.97395435, DT.97396088
NIA Mouse Gene Index U028237
PDB 1YA9
Consensus CDS Project CCDS20912.1
International Mouse Phenotyping Consortium Status Apoe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038239 VEGA Gene Model | MGI Sequence Detail 3058 C57BL/6J ±  kb
transcript OTTMUST00000098456 VEGA | MGI Sequence Detail 1386 Not Applicable 
polypeptide OTTMUSP00000055344 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(8) UniProt(13)
Polymorphisms
RFLP(8) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A/E
Protein Ontology PR:000004155 apolipoprotein E
References
(Earliest) J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
(Latest) J:223014 Singh NK, et al., Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat Commun. 2015;6:7450
All references(1702)
Disease annotation references (9)
Other
accession IDs
MGD-MRK-1376, MGI:2141887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory