About   Help   FAQ
Apoe
Gene Detail
 Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057
STS D7Mit57
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr7:19696109-19699166 bp, - strand
From VEGA annotation of GRCm38

  3058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Apoe

Human
homologs
Human Homolog APOE, apolipoprotein E
NCBI Gene ID 348
neXtProt AC  NX_P02649
Human Synonyms  AD2, LDLCQ5, LPG
Human Chr (Location)  19q13.2; chr19:44905782-44909393 (+)  GRCh38
Disease Associations  (6) Diseases Associated with Human APOE
Alleles
and
phenotypes
All alleles(40) : Targeted(19) Gene trapped(19) Transgenic(1) Spontaneous(1)
 
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
 
Human Diseases Modeled Using Mouse Apoe (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(10)
Gene Ontology
(GO)
classifications
All GO classifications: (113 annotations)
Process aging, artery morphogenesis, ...
Component blood microparticle, cell surface, ...
Function antioxidant activity, beta-amyloid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (249)    Tissues (171)    Images (62)
Theiler Stages: 11, 13, 15, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 169
Northern blot 30
RT-PCR 50
cDNA source data(1787)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(1799) Genomic(2) cDNA(1787) Primer pair(4) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000038239 (Evidence)
Ensembl Gene ModelENSMUSG00000002985 (Evidence)
Entrez Gene11816 (Evidence)
UniGene305152
DFCITC1573648, TC1687215
DoTSDT.87073740, DT.91406850, DT.91569392, DT.94158372, DT.97395435, DT.97396088
NIA Mouse Gene IndexU028237
PDB1YA9
Consensus CDS ProjectCCDS20912.1
International Mouse Knockout Project StatusApoe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038239 VEGA Gene Model | MGI Sequence Detail 3058 C57BL/6J ±  kb
transcript OTTMUST00000098456 VEGA | MGI Sequence Detail 1386 Not Applicable 
polypeptide OTTMUSP00000055344 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(4) UniProt(13)
Polymorphisms RFLP(8) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004155 apolipoprotein E
References (Earliest) J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
(Latest) J:206533 Hyvarinen K, et al., The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice. BMC Genomics. 2013;14:709
All references(1559)
Other
accession IDs
MGD-MRK-1376, MGI:2141887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory