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Aplp2 Gene Detail
Summary
  • Symbol
    Aplp2
  • Name
    amyloid beta precursor-like protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88047
    NCBI Gene: 11804
  • Alliance
    genome feature page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31060853-31123111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.66 cM, cytoband A2-B
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1486 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88047
 protein coding gene Chr9:31060853-31123144 (-)
129S1/SvImJ ENSMUSG00200007437
 protein coding gene Chr9:28059551-28121811 (-)
A/J ENSMUSG00195006061
 protein coding gene Chr9:27871520-27933781 (-)
AKR/J ENSMUSG00220010372
 protein coding gene Chr9:27901239-27963499 (-)
BALB/cJ ENSMUSG00180006748
 protein coding gene Chr9:27999976-28062242 (-)
C3H/HeJ ENSMUSG00175018624
 protein coding gene Chr9:27980512-28042768 (-)
C57BL/6NJ ENSMUSG00215007005
 protein coding gene Chr9:27956379-28018646 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031937
 protein coding gene Chr9:26938463-26998232 (-)
CAST/EiJ ENSTCUG00005018678
 protein coding gene Chr9:27961075-28021878 (-)
CBA/J ENSMUSG00210022067
 protein coding gene Chr9:28012413-28072965 (-)
DBA/2J ENSMUSG00185002247
 protein coding gene Chr9:28052823-28115084 (-)
FVB/NJ ENSMUSG00205003902
 protein coding gene Chr9:28355112-28417370 (-)
JF1/MsJ ENSUMUG00000011374
 protein coding gene Chr9:28224752-28287586 (-)
LP/J ENSMUSG00230005144
 protein coding gene Chr9:28489884-28552137 (-)
NOD/ShiLtJ ENSMUSG00190005641
 protein coding gene Chr9:28092278-28154537 (-)
NZO/HlLtJ ENSMUSG00225014381
 protein coding gene Chr9:28470127-28530608 (-)
PWK/PhJ ENSLUMG00010009224
 protein coding gene Chr9:28093567-28154461 (-)
SPRET/EiJ ENSMSPG00010002059
 protein coding gene Chr9:28459511-28518444 (-)
WSB/EiJ ENSIUOG00005015483
 protein coding gene Chr9:27534844-27595476 (-)



Homology
more
  • Human Ortholog
    APLP2, amyloid beta precursor like protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APLP2, amyloid beta precursor like protein 2
  • Synonyms
    APLP-2, APPH, APPL2, CDEBP
  • Links
    NCBI Gene ID: 334
    UniProt: Q06481

  • Chr Location
    11q24.3; chr11:130068147-130144811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for two different targeted alleles show embryonic lethality, or viability and fertility with increased copper levels in cerebral cortex and liver. Double knockouts with App show high mortality, reduced growth, and neurological symptoms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    11
  • cDNA Data
    400
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031996 Ensembl Gene Model | MGI Sequence Detail 62259 C57BL/6J ±  kb
    transcript ENSMUST00000072634 Ensembl | MGI Sequence Detail 3634 Not Applicable  
    polypeptide ENSMUSP00000072428 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000004137 amyloid beta precursor like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008155 Amyloidogenic glycoprotein
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR011993 PH-like domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    • GlyGen
      Q06335 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 409
      Genomic 7
      cDNA 401
      Other 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1361, MGI:2143122
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 12
      Gene Ontology 15
      Phenotypes 71
    • Earliest
      J:30521 Clarke L, et al., The structure and function of yeast centromeres. Annu Rev Genet. 1985;19:29-55
    • Latest
      J:388210 Lee SH, et al., APP family in inhibitory neurons controls inhibitory recruitment and short-term plasticity in the hippocampus. Mol Brain. 2026 Mar 29;19(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory