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Aplp2
Gene Detail
 Symbol
Name
ID
Aplp2
amyloid beta (A4) precursor-like protein 2
MGI:88047
Feature Type protein coding gene
Genetic Map
Chromosome 9
16.66 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:31149557-31211815 bp, - strand
From NCBI annotation of GRCm38

  62259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Aplp2

Human
homologs
Human Homolog APLP2, amyloid beta (A4) precursor-like protein 2
NCBI Gene ID 334
neXtProt AC  NX_Q06481
Human Synonyms  APLP-2, APPH, APPL2, CDEBP
Human Chr (Location)  11q24; chr11:130069821-130144811 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for two different targeted alleles show embryonic lethality, or viability and fertility with increased copper levels in cerebral cortex and liver. Double knockouts with App show high mortality, reduced growth, and neurological symptoms.
 
Phenotype Images(1)
Interactions
Aplp2 interacts with 243 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular copper ion homeostasis, cholesterol metabolic process, ...
Component cell, extracellular vesicular exosome, ...
Function DNA binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (36)    Tissues (8)    Images (20)
Theiler Stages: 4, 23
Assay TypeResults
Immunohistochemistry 4
RNA in situ 32
cDNA source data(399)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(408) Genomic(7) cDNA(400) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000031996 (Evidence)
Entrez Gene11804 (Evidence)
UniGene19133
DFCITC1573897, TC1580588, TC1590246, TC1590275
DoTSDT.101310293, DT.101310295, DT.103574185, DT.55250784, DT.91302338, DT.91411780, DT.94301317, DT.97370097, DT.99868274
NIA Mouse Gene IndexU030644
Consensus CDS ProjectCCDS52748.1, CCDS52749.1
International Mouse Knockout Project StatusAplp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11804 NCBI Gene Model | MGI Sequence Detail 62259 C57BL/6J ±  kb
transcript NM_001102455 RefSeq | MGI Sequence Detail 3658 C57BL/6 
polypeptide Q06335 UniProt | EBI | MGI Sequence Detail 707 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(12)
Polymorphisms RFLP(1) : SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008155 Amyloidogenic glycoprotein
InterPro IPR011178 Amyloidogenic glycoprotein, copper-binding
InterPro IPR024329 Amyloidogenic glycoprotein, E2 domain
InterPro IPR008154 Amyloidogenic glycoprotein, extracellular
InterPro IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
InterPro IPR015849 Amyloidogenic glycoprotein, heparin-binding
InterPro IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
InterPro IPR019543 Beta-amyloid precursor protein C-terminal
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
Protein Ontology PR:000004137 amyloid-like protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:30521 Clarke L, et al., The structure and function of yeast centromeres. Annu Rev Genet. 1985;19:29-55
(Latest) J:207796 Choi HY, et al., APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
All references(90)
Other
accession IDs
MGD-MRK-1361, MGI:2143122

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory