Cat4
Gene Detail

Symbol Name ID

Cat4 dominant cataract 4 MGI:88040

Synonyms

anterior pyramidal cataract, Apc-1, Apcat1, Apcat-1, Apyc, Pcs-2, polar cataract and small eye 2

Feature Type

heritable phenotypic marker

Genetic Map

Chromosome 8
Syntenic

Mapping data(1)

Alleles and phenotypes

All alleles(3) : Spontaneous(1) Radiation induced(2)
 

Homozygotes and heterozygous mutants display eye defects with some or all of: anterior lens opacity with polar adhesions, corneal opacity, anscoria, iris dysplasia, and microphthalmia. For some alleles, homozygotes show anophthalmia or embryonic lethality.

 
Human Diseases Modeled Using Mouse Cat4 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (1 annotations)

Process

camera-type eye development

External Resources: FuncBase

Other database links

Entrez Gene

109738

References

(Earliest) J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
(Latest) J:49424 Grimes PA, et al., Abnormal eye development associated with Cat4a, a dominant mouse cataract mutation on chromosome 8. Invest Ophthalmol Vis Sci. 1998 Sep;39(10):1863-9
All references(7)

Other accession IDs

MGD-MRK-1318, MGD-MRK-13189, MGD-MRK-1348, MGD-MRK-1349, MGD-MRK-1350, MGD-MRK-1383