Chrna3
Gene Detail

Symbol Name ID

Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 MGI:87887

Synonyms

(a)3, A730007P14Rik, Acra3, Acra-3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit

Feature Type

protein coding gene

Genetic Map

Chromosome 9

29.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:55011343-55026559 bp, - strand From NCBI annotation of GRCm38   15217 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:591  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrna3

Human homologs

Human Homolog		CHRNA3, cholinergic receptor, nicotinic, alpha 3 (neuronal)
NCBI Gene ID		1136
neXtProt AC		NX_P32297
Human Synonyms		LNCR2, NACHRA3, PAOD2
Human Chr (Location)		15q24; chr15:78885394-78913637 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHRNA3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for a targeted null mutation show high postnatal and postweaning mortality. Mutants show reduced bladder contractility resulting in enlarged bladder, infections and urinary stones. Eyes are small, with dilated ocular pupils.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	activation of transmembrane receptor protein tyrosine kinase activity, behavioral response to nicotine, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (192)    Tissues (63)    Images (36)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	167
Northern blot	8
RT-PCR	17

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032303 (Evidence)
Entrez Gene	110834 (Evidence)
UniGene	63569
DFCI	TC1581643, TC1608660
DoTS	DT.87037961, DT.94290303
NIA Mouse Gene Index	U030893
Consensus CDS Project	CCDS23199.1
International Mouse Knockout Project Status	Chrna3

Sequences

Length	Strain/Species
genomic	110834	NCBI Gene Model | MGI Sequence Detail	15217	C57BL/6J
transcript	NM_145129	RefSeq | MGI Sequence Detail	3123	C57BL/6
polypeptide	Q8R4G9	UniProt | EBI | MGI Sequence Detail	499	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005456	neuronal acetylcholine receptor subunit alpha-3

Graphical View of Protein Domain Structure

References

(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:190436 Chakrabarty K, et al., Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open. 2012 Aug 15;1(8):693-704
All references(59)

Other accession IDs

MGD-MRK-1056, MGD-MRK-1060, MGI:2445169