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Chrna3 Gene Detail
Summary
  • Symbol
    Chrna3
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 3
  • Synonyms
    (a)3, A730007P14Rik, Acra3, Acra-3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:87887
    NCBI Gene: 110834
  • Gene Overview
    MyGene.info: CHRNA3
Location & Maps
more
  • Sequence Map
    Chr9:55011343-55026559 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15217 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.84 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CHRNA3, cholinergic receptor nicotinic alpha 3 subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHRNA3, cholinergic receptor nicotinic alpha 3 subunit
    Orthology source: HomoloGene
  • Synonyms
    LNCR2, NACHRA3, PAOD2
  • Links
    NCBI Gene ID: 1136
    neXtProt AC: NX_P32297

  • Chr Location
    15q24; chr15:78593052-78621295 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation show high postnatal and postweaning mortality. Mutants show reduced bladder contractility resulting in enlarged bladder, infections and urinary stones. Eyes are small, with dilated ocular pupils.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110834 NCBI Gene Model | MGI Sequence Detail 15217 C57BL/6J ±  kb
transcript NM_145129 RefSeq | MGI Sequence Detail 3123 C57BL/6  
polypeptide Q8R4G9 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005456 neuronal acetylcholine receptor subunit alpha-3
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 23
    cDNA 21
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1056, MGD-MRK-1060, MGI:2445169
References
more
  • Summaries
    All 60
    Developmental Gene Expression 11
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
  • Latest
    J:221646 Foong JP, et al., Changes in Nicotinic Neurotransmission during Enteric Nervous System Development. J Neurosci. 2015 May 6;35(18):7106-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory