Tg(tetO/CMV-ATP2B4,-lacZ)1Husa
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-ATP2B4,-lacZ)1Husa
• Name: transgene insertion 1, Mansoor Husain
• MGI ID: MGI:6159127
• Synonyms: hPMCA4b
• Transgene: Tg(tetO/CMV-ATP2B4,-lacZ)1Husa Location: unknown
• Alliance: Tg(tetO/CMV-ATP2B4,-lacZ)1Husa page

Transgene origin

• Strain of Origin: 129/SvJ

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-ATP2B4,-lacZ)1Husa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATP2B4 (493)

  Atp2b4

  (MGI:88111)

• Mutation details: The transgenic construct contains a bidirectional CMV promoter with a tetracycline operator (tetO) site, pBiGNot1, directing expression of a b-galactosidase (lacZ) reporter followed by a b-globin polyA signal on one side and human ATP2B4 cDNA squence on the other side. (J:128144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128144 Gros R, et al., Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure. Circ Res. 2003 Oct 3;93(7):614-21
• All: 2 reference(s)