Tg(ACTB-Wld)#Cole
Transgene Detail
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Symbol: |
Tg(ACTB-Wld)#Cole |
Name: |
transgene insertion, Michael Coleman |
MGI ID: |
MGI:5911098 |
Transgene: |
Tg(ACTB-Wld)#Cole Location: unknown
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Alliance: |
Tg(ACTB-Wld)#Cole page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(ACTB-Wld)#Cole expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Wld (MGI:98952) |
expresses Wlds fusion gene |
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Mutation details: A construct consisting of the human beta actin promoter followed by the cDNA for Wlds that is an in-frame fusion of exon 1 and 2 of Ube4b to exon 2 onwards of Nmnat1, was injected into the pronuclei of fertilized (C57BL/6 x CBA)F1 eggs that do not express Wlds. Four lines were established (4830, 4836, 4839 and 4858) and expression levels of this transgene varied from considerably lower than to similar to that of Wlds in the C57Bl/6Ola strain.
(J:72936)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:72936 Mack TG, et al., Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci. 2001 Dec;4(12):1199-206 |
All: |
1 reference(s) |
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