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Tg(Myh6-MYL2*E22K)4Dsc
Transgene Detail
Summary
Symbol: Tg(Myh6-MYL2*E22K)4Dsc
Name: transgene insertion 4, Danuta Szczesna-Cordary
MGI ID: MGI:5908892
Synonyms: Tg-E22K
Transgene: Tg(Myh6-MYL2*E22K)4Dsc  Location: unknown  
Alliance: Tg(Myh6-MYL2*E22K)4Dsc page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-MYL2*E22K)4Dsc expresses 1 gene
 
Mutation detailsThe mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third drives the cardiac-specific expression of a mutated human myosin regulatory light chain 2 cDNA that contains an amino acid substitution of lysine for glutamic acid at position 22 (E22K, a familial hypertrophic cardiomyopathy-linked mutation). An N-terminal myc sequence was added to aid in identification of the human transgenic protein. Two lines were generated, L2 and L4. Line 4 is entered as the representative line. (J:101467)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:101467 Szczesna-Cordary D, et al., The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. J Cell Sci. 2005 Aug 15;118(Pt 16):3675-83
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory