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Tg(EEF1A1-Gnas*R201C)184Pabi
Transgene Detail
Summary
Symbol: Tg(EEF1A1-Gnas*R201C)184Pabi
Name: transgene lentiviral insertion 184, Paolo Bianco
MGI ID: MGI:5883023
Synonyms: EF1alpha-GsalphaR201C
Transgene: Tg(EEF1A1-Gnas*R201C)184Pabi  Location: unknown  
Alliance: Tg(EEF1A1-Gnas*R201C)184Pabi page
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:240241
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(EEF1A1-Gnas*R201C)184Pabi expresses 1 gene
 
Mutation detailsA lentiviral construct containing Gnas with an arginine to cysteine change at codon 201 (R201C) under the constitutive human elongation factor 1 alpha promoter was used to generate mice. Two founders were established: 184 and 33A. Line 184 is entered as a representative line. (J:240241)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:240241 Saggio I, et al., Constitutive expression of Gsalpha(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history. J Bone Miner Res. 2014 Nov;29(11):2357-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory