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Tg(Cyp17a1-NGF)2456Oje
Transgene Detail
Summary
Symbol: Tg(Cyp17a1-NGF)2456Oje
Name: transgene insertion 2456, Sergio R Ojeda
MGI ID: MGI:5662266
Synonyms: 17NF
Transgene: Tg(Cyp17a1-NGF)2456Oje  Location: unknown  
Alliance: Tg(Cyp17a1-NGF)2456Oje page
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cyp17a1-NGF)2456Oje expresses 1 gene
 
Mutation detailsThe human NGF gene is targeted to thecal-interstitial cells by the mouse 17alpha-hydroxylase promoter. RNase protection assays confirmed ovarian mRNA expression and to a much lesser extent, expression in the adrenal gland, in the kidney and the liver.Two lines, 2380 and 2456, were generated and exhibited similar phenotypes. Line 2456 was studied further. (J:158186)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:158186 Dissen GA, et al., Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans. Endocrinology. 2009 Jun;150(6):2906-14
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory