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Tg(tetO-SPTBN2*)#Lpwr
Transgene Detail
Summary
Symbol: Tg(tetO-SPTBN2*)#Lpwr
Name: transgene insertion, Laura PW Ranum
MGI ID: MGI:5662095
Synonyms: TRE-SPdelta39
Transgene: Tg(tetO-SPTBN2*)#Lpwr  Location: unknown  
Alliance: Tg(tetO-SPTBN2*)#Lpwr page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(tetO-SPTBN2*)#Lpwr expresses 1 gene
 
Mutation detailsThis transgene consists of the tetracycline-response element (TRE), minimal CMV promoter, and human SPTBN2 cDNA containing the American SCA5 mutation (1592_1630del) which results in a 39 bp in-frame deletion. (J:215593)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:215593 Armbrust KR, et al., Mutant beta-III spectrin causes mGluR1alpha mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. J Neurosci. 2014 Jul 23;34(30):9891-904
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory