Tg(CMV-ATXN3*135Q)CPama
Transgene Detail
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Symbol: |
Tg(CMV-ATXN3*135Q)CPama |
Name: |
transgene insertion C, Patricia Maciel |
MGI ID: |
MGI:5646300 |
Synonyms: |
CMVMJD135 |
Transgene: |
Tg(CMV-ATXN3*135Q)CPama Location: unknown
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Alliance: |
Tg(CMV-ATXN3*135Q)CPama page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CMV-ATXN3*135Q)CPama expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ATXN3 (4287) |
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Mutation details: The human ATXN3c cDNA variant carrying a repeat tract with the sequence (CAG)2CAAAAGCAGCAA(CAG)129, coding for 135 glutamines, is under the regulation of the CMV promoter. This line has two copies of the transgene and expresses the human mRNA at near-endogenous levels in the cerebellum, brainstem, forebrain and spinal cord. With breeding, mice show intergenerational CAG repeat length variation, mostly towards contraction.
(J:222991)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:222991 Silva-Fernandes A, et al., Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease. Neurotherapeutics. 2014 Apr;11(2):433-49 |
All: |
13 reference(s) |
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