Del(6Dlx6-Dlx5)1Tlu Cytogenetic Marker Detail

Summary

• Symbol
  Del(6Dlx6-Dlx5)1Tlu
• Name
  deletion, Chr 6, Thomas Lufkin 1

• Feature Type
  chromosomal deletion
• IDs
  MGI:5583955

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, Syntenic

Human Diseases

• Diseases
  1 with Del(6Dlx6-Dlx5)1Tlu mouse models

Human Disease

Mouse Models

split hand-foot malformation 1

IDs

split hand-foot malformation 1      

DOID:0090021
ICD10CM:Q71.6
OMIM:183600
ORDO:2440

View 1 model

Mouse Models

Human Disease Modeled: split hand-foot malformation 1

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(6Dlx6-Dlx5)1Tlu/Del(6Dlx6-Dlx5)1Tlu	Not Specified	J:76480	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  47 phenotypes from 1 allele in 2 genetic backgrounds
  4 phenotypes from multigenic genotypes
  10 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 11

  Diseases 1

  Phenotypes 10
• Earliest
  J:76480 Robledo RF, et al., The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1;16(9):1089-101
• Latest
  J:302446 Rubin AN, et al., Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons. eNeuro. 2020 Nov/Dec;7(6):ENEURO.0211-20.2020