Tg(Prnp-SNAP25/HTT*150Q)8Xjl
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNAP25/HTT*150Q)8Xjl
• Name: transgene insertion 8, Xiao-Jiang Li
• MGI ID: MGI:5575507
• Synonyms: SNAP25-150Q
• Transgene: Tg(Prnp-SNAP25/HTT*150Q)8Xjl Location: unknown
• Alliance: Tg(Prnp-SNAP25/HTT*150Q)8Xjl page

Appearance of old Tg(Prnp-SNAP25/HTT*150Q)8Xjl/0 (150Q) mouse and control littermate at 13 months of age

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNAP25/HTT*150Q)8Xjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: Exon 1 of HTT containing 150 CAG repeats (150Q) was fused to the C terminus of SNAP25 and is under the control of the mouse prion promoter. Three lines were established: 2, 8, and 15. (J:201806)

Schematic of the Tg(Prnp-SNAP25/HTT*150Q)8Xjl transgene

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:201806 Xu Q, et al., Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J Cell Biol. 2013 Sep 30;202(7):1123-38
• All: 1 reference(s)