Tg(Upk2-icre/ERT2)1Ccc
Transgene Detail

Summary

• Symbol: Tg(Upk2-icre/ERT2)1Ccc
• Name: transgene insertion 1, Carlos Cordon-Cardo
• MGI ID: MGI:5568245
• Synonyms: TgUICBAC
• Transgene: Tg(Upk2-icre/ERT2)1Ccc Location: unknown
• Alliance: Tg(Upk2-icre/ERT2)1Ccc page

Generation of Tg(Upk2-icre/ERT2)1Ccc

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Upk2-icre/ERT2)1Ccc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Upk2 (MGI:98913)

• Mutation details: The bMQ-343M5 mouse bacterial artificial chromosome (BAC) containing the entire Upk2 gene (and parts of the Foxr1 and Cxcr5 genes, and the Bcl9l gene) was modified by inserting the icre/ERT2 fusion protein-coding sequence followed by a polyA signal into the ATG initiation start site of the Upk2 gene. The transgenic construct was injected into fertilized C57BL/6 x CBA)F1 mouse eggs. Two founders were obtained (#1 having 2 copies of the transgene and #5 with 4 copies). Only #1 was able to produce offspring, and this line was used for further analyses. (J:209640)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Upk2 (mouse) Summary of all recombinase alleles driven by Upk2. Comparative matrix view of recombinase activities Alliance mouse Upk2 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(Upk2-icre/ERT2)1Ccc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:209640 Shen TH, et al., A BAC-based transgenic mouse specifically expresses an inducible Cre in the urothelium. PLoS One. 2012;7(4):e35243
• All: 7 reference(s)