Tg(Hdc-cre)#Jmz
Transgene Detail

Summary

• Symbol: Tg(Hdc-cre)#Jmz
• Name: transgene insertion, Jeffrey M Zigman
• MGI ID: MGI:5562453
• Synonyms: HDC-Cre`
• Transgene: Tg(Hdc-cre)#Jmz Location: unknown
• Alliance: Tg(Hdc-cre)#Jmz page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Hdc-cre)#Jmz expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hdc (MGI:96062)

• Mutation details: A BAC (RP24-14N14) containing the entire histidine decarboxylase (Hdc) gene was modified in bacterial cells, replacing the first 47 amino acids of exon 2, intron 1, and exon 1 of Hdc with the cre recombinase coding sequence, SV40 polyadenylation signal and Frt-flanked kanamycin marker. Flp recombination removed the kanamycin cassette. Pronuclear injection of the verified construct produced founder mice. Multiple founders were generated. One founder was verified to have the transgene and produce the expected cre activity in the CNS. (J:194386)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hdc (mouse) Summary of all recombinase alleles driven by Hdc. Alliance mouse Hdc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194386 Yanovsky Y, et al., Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness. Front Syst Neurosci. 2012;6:23
• All: 5 reference(s)