Tg(PDGFB-APPInd)F17Plhn
Transgene Detail

Summary

• Symbol: Tg(PDGFB-APPInd)F17Plhn
• Name: transgene insertion F17, Pyung-Lim Han
• MGI ID: MGI:5550581
• Synonyms: Tg-betaCTF99
• Transgene: Tg(PDGFB-APPInd)F17Plhn Location: unknown
• Alliance: Tg(PDGFB-APPInd)F17Plhn page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-APPInd)F17Plhn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Indiana mutation.

• Mutation details: This transgene consists of the platelet-derived growth factor beta promoter, the human APP signal sequence, the amyloid beta containing carboxy-terminal 99 amino acids of APP with the Indiana V717F mutation and the SV40 polyadenylation sequence. The Kozak sequence (GACC) was introduced in front of the ATG codon of the signal sequence to increase translation efficiency. 16 Founder lines were established. This is the highest expressing line. (J:107982)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107982 Lee KW, et al., Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein. Neurobiol Dis. 2006 Apr;22(1):10-24
• All: 2 reference(s)