Tg(SNCA)OVX37Rwm
Transgene Detail

Summary

• Symbol: Tg(SNCA)OVX37Rwm
• Name: transgene insertion OVX37, Richard Wade-Martins
• MGI ID: MGI:5544307
• Synonyms: SNCA-OVX
• Transgene: Tg(SNCA)OVX37Rwm Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Tg(SNCA)OVX37Rwm page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SNCA)OVX37Rwm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: This transgene consists of a BAC carrying the complete 111-kb wild-type human SNCA locus. This line overexpresses the human protein at nearly twice the endogenous level of the mouse protein. Fluorescence in situ hybridization analysis identified a single site of integration near the centromere of chromosome 4. (J:201991)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:201991 Janezic S, et al., Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4016-25
• All: 10 reference(s)