Tg(Camk2a-DISC1)37Asaw
Transgene Detail
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Symbol: |
Tg(Camk2a-DISC1)37Asaw |
Name: |
transgene insertion 37, Akira Sawa |
MGI ID: |
MGI:5486141 |
Synonyms: |
DN-DISC1 |
Transgene: |
Tg(Camk2a-DISC1)37Asaw Location: unknown
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Alliance: |
Tg(Camk2a-DISC1)37Asaw page
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Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Camk2a-DISC1)37Asaw expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
DISC1 (27185) |
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Mutation details: The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the high expressing line.
(J:124683)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:124683 Hikida T, et al., From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6 |
All: |
5 reference(s) |
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