Tg(Hoxb7-Ret)LCos
Transgene Detail

Summary

• Symbol: Tg(Hoxb7-Ret)LCos
• Name: transgene insertion L, Frank Costantini
• MGI ID: MGI:5426785
• Transgene: Tg(Hoxb7-Ret)LCos Location: unknown
• Alliance: Tg(Hoxb7-Ret)LCos page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hoxb7-Ret)LCos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ret (MGI:97902)

• Mutation details: The transgene consists of a mouse Ret cDNA encoding the RET9 isoform fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The construct retained all 201 bp of endogenous Ret9 non-coding sequences, including the out-of-frame upstream ATG at position 169, which presumably competes with the bonafide in-frame Ret9 initiation codon at position 201, resulting in a lower level of Ret9 protein. This construct does not generate dominant renal defects. (J:79420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:79420 Batourina E, et al., Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet. 2001 Jan;27(1):74-8
• All: 2 reference(s)