Tg(H2-L^d/H2-D^d)LD8Gja
Transgene Detail

Summary

• Symbol: Tg(H2-L^d/H2-D^d)LD8Gja
• Name: transgene insertion LD8, Gilbert Jay
• MGI ID: MGI:5305227
• Synonyms: LD8, Tg(H2Ldalfa1/H2Ldalfa2/H2Ddalfa3)LD8, Tg(H2Ldalpha1/H2Ldalpha2/H2Ddalpha3)LD8
• Transgene: Tg(H2-L^d/H2-D^d)LD8Gja Location: unknown
• Alliance: Tg(H2-L^d/H2-D^d)LD8Gja page

Transgene origin

• Strain of Origin: CD-1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-L^d/H2-D^d)LD8Gja expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-D1 (MGI:95896)
  mouse	H2-L (MGI:95912)

• Mutation details: This transgene encodes a chimeric major histocompatibility (MHC) class I molecule composed of the alpha1 and alpha2 domains of H2-L^d joined to the alpha3, transmembrane and cytoplasmic domains of H2-D^d. (J:180043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:180043 Johansson MH, et al., Alpha1/alpha2 domains of H-2D(d), but not H-2L(d), induce "missing self" reactivity in vivo--no effect of H-2L(d) on protection against NK cells expressing the inhibitory receptor Ly49G2. Eur J Immunol. 1998 Dec;28(12):4198-206
• All: 1 reference(s)