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Del(7Slx1b-Sept1)4Aam Cytogenetic Marker Detail
Summary
  • Symbol
    Del(7Slx1b-Sept1)4Aam
  • Name
    deletion, Chr 7, Alea A Mills 4
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:5291501
Location &
Maps
more
  • Sequence Map
    Chr7:126689468-127233130 bp
  • From MGI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, Syntenic
Human Diseases
more
  • Diseases
    1 with Del(7Slx1b-Sept1)4Aam mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with this deletion exhibit decreased body size, hyperactivity, and stereotypic behavior.
References
more
  • Summaries
    All 12
    Diseases 2
    Phenotypes 11
  • Earliest
    J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17076-81
  • Latest
    J:263550 Wang W, et al., Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome. J Neurosci. 2018 Jun 27;38(26):5939-5948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory