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Del(7Slx1b-Sept1)4Aam Cytogenetic Marker Detail
Summary
  • Symbol
    Del(7Slx1b-Sept1)4Aam
  • Name
    deletion, Chr 7, Alea A Mills 4
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:5291501
Location & Maps
more
  • Genetic Map
    Chromosome 7, Syntenic
Human Diseases
more
  • Diseases
    1 with Del(7Slx1b-Sept1)4Aam mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Targeted
    1
Mice with this deletion exhibit decreased body size, hyperactivity, and stereotypic behavior.
Polymorphisms
less
  • SNPs within 2kb
    2344 from dbSNP Build 137
References
more
  • Summaries
    All 6
    Diseases 4
    Phenotypes 5
  • Earliest
    J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 3;
  • Latest
    J:219859 Pucilowska J, et al., The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. J Neurosci. 2015 Feb 18;35(7):3190-200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory