Tg(HTT*/EGFP)190Nn
Transgene Detail

Summary

• Symbol: Tg(HTT*/EGFP)190Nn
• Name: transgene insertion 190, Nobuyuki Nukina
• MGI ID: MGI:5052377
• Synonyms: HD190QG
• Transgene: Tg(HTT*/EGFP)190Nn Location: unknown
• Alliance: Tg(HTT*/EGFP)190Nn page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(HTT*/EGFP)190Nn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The human HTT promoter and exon 1, containing expanded CAG repeats, were fused to EGFP. The expanded repeat segment includes about 150 CAG repeats. This line carries 2 main fragments, one with 190 CAG repeats and one with 155 CAG repeats. (J:174269)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:174269 Kotliarova S, et al., Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. J Neurochem. 2005 May;93(3):641-53
• All: 2 reference(s)