Tg(Myh6/tetO-Itpr1)22.3Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Itpr1)22.3Jmol
• Name: transgene insertion 22.3, Jeffery D Molkentin
• MGI ID: MGI:4940826
• Synonyms: sponge transgenic
• Transgene: Tg(Myh6/tetO-Itpr1)22.3Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-Itpr1)22.3Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Knockdown)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-Itpr1)22.3Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Itpr1 (MGI:96623)

• Mutation details: FLAG-tagged cDNA encoding mouse Iptr1 "sponge protein" (glutathione S-transferase fused to Itpr1 residues 224-604; also called G224) was cloned into the mouse inducible Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) tetO promoter. (J:169368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169368 Nakayama H, et al., The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res. 2010 Sep 3;107(5):659-66
• All: 2 reference(s)