Tg(Prnp-TARDBP*A315T)23Jlel
Transgene Detail

Summary

• Symbol: Tg(Prnp-TARDBP*A315T)23Jlel
• Name: transgene insertion 23, Jeffrey L Elliott
• MGI ID: MGI:4839643
• Synonyms: A315T TDP-43 line 23
• Transgene: Tg(Prnp-TARDBP*A315T)23Jlel Location: unknown
• Alliance: Tg(Prnp-TARDBP*A315T)23Jlel page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-TARDBP*A315T)23Jlel expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The mouse promoter drives neuronal expression of the human cDNA with point mutations that result in the amino acid substitution of threonine for alanine at position 315 (A315T). This mutation was identified in human patients with amyotrophic lateral sclerosis with TARDBP proteinopathies. Four lines were established (23, 27, 35, and 61). (J:165985)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:165985 Stallings NR, et al., Progressive motor weakness in transgenic mice expressing human TDP-43. Neurobiol Dis. 2010 Nov;40(2):404-14
• All: 2 reference(s)