Tg(Myh6-PRKAG2*T400N)1Feah
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKAG2*T400N)1Feah
• Name: transgene insertion 1, Fehaan Ahmad
• MGI ID: MGI:4818807
• Synonyms: TG^T400N
• Transgene: Tg(Myh6-PRKAG2*T400N)1Feah Location: unknown
• Alliance: Tg(Myh6-PRKAG2*T400N)1Feah page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PRKAG2*T400N)1Feah expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

• Mutation details: The mouse promoter drives cardiac-specific expression of the human cDNA with a C to A transition that results in the amino acid substitution of asparagine for threonine at position 400 (T400N). (J:123005)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:123005 Banerjee SK, et al., A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia. Biochem Biophys Res Commun. 2007 Aug 24;360(2):381-7
• All: 3 reference(s)