Tg(Fabp4-LMNA*R482Q)17CCdl
Transgene Detail
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Symbol: |
Tg(Fabp4-LMNA*R482Q)17CCdl |
Name: |
transgene insertion 17C, Constantine D Londos |
MGI ID: |
MGI:4454324 |
Transgene: |
Tg(Fabp4-LMNA*R482Q)17CCdl Location: unknown
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Alliance: |
Tg(Fabp4-LMNA*R482Q)17CCdl page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Fabp4-LMNA*R482Q)17CCdl expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
LMNA (4000) |
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Mutation details: The transgene contains the fatty acid binding protein 4 (Fabp4/aP2) promoter driving adipose-specific expression of a cDNA encoding the C isoform of human lamin A with substitution of glutamine for arginine at amino acid position 482 followed by an SV40 splice site and poly(A) signal. This amino acid substitution was identified in patients with familial partial lipodystrophy of the Dunnigan type (FPLD2). A mouse line was generated from founder 17C.
(J:149858)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:149858 Wojtanik KM, et al., The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation. J Lipid Res. 2009 Jun;50(6):1068-79 |
All: |
1 reference(s) |
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