Tg(MMTV-cre)FMam
Transgene Detail

Summary

• Symbol: Tg(MMTV-cre)FMam
• Name: transgene insertion F, Lothar Hennighausen
• MGI ID: MGI:4453858
• Synonyms: F-line, MC(F), Tg(MMTV-cre)22Mam
• Transgene: Tg(MMTV-cre)FMam Location: unknown
• Alliance: Tg(MMTV-cre)FMam page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(MMTV-cre)FMam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	MMTV

• Mutation details: This transgene directs the expression of Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat. The viral MMTV promoter directed expression of Cre recombinase in the secretory epithelium of the mammary gland, the salivary gland and in the female germline. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, and various cells of the immune system. Little background recombination was observed in the lung, kidney, liver and brain tissues. (J:67925)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-cre)FMam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:76553 Cui Y, et al., Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem. 2002 May 17;277(20):17830-5
• All: 18 reference(s)