Tg(GFAP-HTT*160Q)1Xjl
Transgene Detail

Summary

• Symbol: Tg(GFAP-HTT*160Q)1Xjl
• Name: transgene insertion 1, Xiao-Jiang Li
• MGI ID: MGI:4429148
• Synonyms: Htt-160Q
• Transgene: Tg(GFAP-HTT*160Q)1Xjl Location: unknown
• Alliance: Tg(GFAP-HTT*160Q)1Xjl page

Transgene origin

• Strain of Origin: FVB/NCrl

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-HTT*160Q)1Xjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The astrocyte-specific promoter drives expression of the human gene containing an expansion of the trinucleotide repeat to 160 copies (160Q) and followed by a polyadenylation sequence. Several lines were generated (1, 11, and 31). (J:156460)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156460 Bradford J, et al., Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22480-5
• All: 1 reference(s)