nad
Gene Detail

Symbol Name ID

nad spontaneous neuroaxonal dystrophy MGI:4418710

Feature Type

heritable phenotypic marker

Genetic Map

Chromosome Unknown

Alleles and phenotypes

All alleles(1) : Spontaneous(1)
 

As early as 3 weeks of age homozygotes show signs of sensory axonopathy (clasping reflex and ataxia) which progress to paraparesis and morbidity by 6 months of age. Large swollen axons (spheroids) are noted in the brainstem and spinal cord. Males fail to breed, likely due to hindlimb muscle atrophy.

 
Human Diseases Modeled Using Mouse nad (1)    Alleles Annotated to Human Diseases(1)   

References

(Earliest) J:156089 Bouley DM, et al., Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. J Comp Pathol. 2006 Feb-Apr;134(2-3):161-70
All references(1)