About   Help   FAQ
nad Gene Detail
Summary
  • Symbol
    nad
  • Name
    spontaneous neuroaxonal dystrophy
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:4418710
Location & Maps
less
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome Unknown
Human Diseases
more
  • Diseases
    1 with nad mouse models

Human Disease Mouse Models
       Neurodegeneration with Brain Iron Accumulation 2A; NBIA2A   OMIM: 256600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Spontaneous
    1
As early as 3 weeks of age homozygotes show signs of sensory axonopathy (clasping reflex and ataxia) which progress to paraparesis and morbidity by 6 months of age. Large swollen axons (spheroids) are noted in the brainstem and spinal cord. Males fail tobreed, likely due to hindlimb muscle atrophy.
References
more
  • Summaries
    All 1
    Diseases 1
    Phenotypes 1
  • Earliest
    J:156089 Bouley DM, et al., Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. J Comp Pathol. 2006 Feb-Apr;134(2-3):161-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory