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nad
Gene Detail
 Symbol
Name
ID
nad
spontaneous neuroaxonal dystrophy
MGI:4418710
Feature Type heritable phenotypic marker
Genetic Map
Chromosome Unknown
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
 
As early as 3 weeks of age homozygotes show signs of sensory axonopathy (clasping reflex and ataxia) which progress to paraparesis and morbidity by 6 months of age. Large swollen axons (spheroids) are noted in the brainstem and spinal cord. Males fail to breed, likely due to hindlimb muscle atrophy.
 
Human Diseases Modeled Using Mouse nad (1)    Alleles Annotated to Human Diseases(1)   
References (Earliest) J:156089 Bouley DM, et al., Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. J Comp Pathol. 2006 Feb-Apr;134(2-3):161-70
All references(1)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory