Tg(CAG-EGFP,-GLI2*)1Aad
Transgene Detail

Summary

• Symbol: Tg(CAG-EGFP,-GLI2*)1Aad
• Name: transgene insertion 1, Andrzej A Dlugosz
• MGI ID: MGI:4418551
• Synonyms: CLEG2, CLEG2^cond
• Transgene: Tg(CAG-EGFP,-GLI2*)1Aad Location: unknown
• Alliance: Tg(CAG-EGFP,-GLI2*)1Aad page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The CAG promoter was used to drive expression of a construct composed of a floxed EGFP with a strong termination signal followed by a myc tagged dominant active form of GLI2 lacking the N terminal repressor domain (GLI2deltaN). In the absence of cre, EGFPis expressed and downstream GLI2 expression is prevented. Cre expression causes the excision of EGFP and its termination signal thus permitting GLI2 expression. (J:116111, J:154130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116111 Pasca di Magliano M, et al., Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 2006 Nov 15;20(22):3161-73
• All: 5 reference(s)