Tg(Aire-G6pc2/GFP)1Mand
Transgene Detail

Summary

• Symbol: Tg(Aire-G6pc2/GFP)1Mand
• Name: transgene insertion 1, Mark Anderson
• MGI ID: MGI:4367724
• Synonyms: Adig
• Transgene: Tg(Aire-G6pc2/GFP)1Mand Location: unknown
• Alliance: Tg(Aire-G6pc2/GFP)1Mand page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The BAC clone RPCI23, 461E7 was modified by targeted replacement of the coding portion of exon 1, all of exon 2 and part of exon 3 of the Aire gene with a construct containing a beta globin donor and acceptor cassette, a G6pc2/GFP fusion sequence and SV40 polyadenylation signal. The resulting transgene does not express Aire. Two NOD and two C57BL/6 founders were produced. The two NOD founders were propagated. (J:154359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154359 Gardner JM, et al., Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 8;321(5890):843-7
• All: 14 reference(s)