Tg(tetO/CMV-Prnp*,-lacZ)5Mjy
Transgene Detail
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| Symbol: |
Tg(tetO/CMV-Prnp*,-lacZ)5Mjy |
| Name: |
transgene insertion 5, Jiyan Ma |
| MGI ID: |
MGI:4365809 |
| Synonyms: |
pBI-cyPrP-Gal, Tg(TRE/CMV-Prnp*,-lacZ)5Mjy |
| Transgene: |
Tg(tetO/CMV-Prnp*,-lacZ)5Mjy Location: unknown
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| Alliance: |
Tg(tetO/CMV-Prnp*,-lacZ)5Mjy page
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence, Reporter) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Mutation details: Transgenic mice express prion protein in the cytosol (cyPrnP, amino acids 23 to 230, which precisely eliminated the NH2-terminal and the COOH-terminal sequences that are cleaved upon ER entry), and beta-Gal under the regulation of a minimal CMV promoter and a tetracycline-responsive bi-directional promoter. The whole brain beta-Gal staining and Western blot revealed that beta-Gal and cyPrnp expression were largely confined to the forebrain.
(J:80582, J:153494)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:153494 Wang X, et al., Cytoplasmic prion protein induces forebrain neurotoxicity. Biochim Biophys Acta. 2009 Jun;1792(6):555-63 |
| All: |
2 reference(s) |
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Analysis Tools
