Tg(Pbsn-ERG*)1Vv
Transgene Detail
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Symbol: |
Tg(Pbsn-ERG*)1Vv |
Name: |
transgene insertion 1, Valeri Vasioukhin |
MGI ID: |
MGI:4358243 |
Synonyms: |
deltaN-ERG |
Transgene: |
Tg(Pbsn-ERG*)1Vv Location: unknown
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Alliance: |
Tg(Pbsn-ERG*)1Vv page
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Strain of Origin: |
C57BL/6J x CBA
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Pbsn-ERG*)1Vv expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ERG (2078) |
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Mutation details: A transgenic construct containing a rat probasin promoter (Pbsn), beta globin intron, a truncated N-terminal human avian erythroblastosis virus E-26 (v-ets) oncogene related (ERG) cDNA and poly(A) sequences was injected into C57BL/6 X CBA fertilized embryos. Two mouse lines were generated. Founder line 1 had significantly higher levels of the mutant ERG transcript. Truncated ERG protein were higher in Western blots of the ventral prostate with significantly lower levels in dorsolateral and anterior lobes.
(J:131932)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:131932 Klezovitch O, et al., A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2105-10 |
All: |
7 reference(s) |
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