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Tg(ACTB-TNFRSF6B)754Jwu
Transgene Detail
Summary
Symbol: Tg(ACTB-TNFRSF6B)754Jwu
Name: transgene insertion 754 Jiangping Wu
MGI ID: MGI:3843671
Synonyms: DcR3 Tg
Transgene: Tg(ACTB-TNFRSF6B)754Jwu  Location: unknown  
Alliance: Tg(ACTB-TNFRSF6B)754Jwu page
Transgene
origin
Strain of Origin:  C3H x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTB-TNFRSF6B)754Jwu expresses 1 gene
 
Tg(ACTB-TNFRSF6B)754Jwu expression driven by 1 gene
 
Mutation detailsThe construct consists of human full length Dcr3 (TNFRSF6B) cDNA flanked by human beta actin promoter and beta actin poly(A) signal. The construct was injected into fertilized eggs from C3H x C57BL/6 mice. Line 754 was established and analyzed further. (J:148162)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Line 17139 exhibits a phenotype similar to Line 754, including lymphadenopathy, pathologies in skin, kidney and liver and a shortened lifespan in females.
References
Original:  J:148162 Han B, et al., Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. Arthritis Rheum. 2007 Nov;56(11):3748-58
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory