Tg(Myh6/tetO-PRKAG2*N488I)1Chib
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-PRKAG2*N488I)1Chib
• Name: transgene insertion 1, Charles I Berul
• MGI ID: MGI:3841177
• Transgene: Tg(Myh6/tetO-PRKAG2*N488I)1Chib Location: unknown
• Alliance: Tg(Myh6/tetO-PRKAG2*N488I)1Chib page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-PRKAG2*N488I)1Chib expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

• Mutation details: A fusion promoter with tetO was used to drive repressible, cardiac expression of the human gene with an T to A substitution at position 1553 that results in the amino acid substitution of asparagine with isoleucine at position 488 (N488I). Thirteen lines were created with 2 exhibiting robust expression and phenotype. No line numbers were given. (J:145090)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:145090 Wolf CM, et al., Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008 Jan 15;117(2):144-54
• All: 1 reference(s)