Tg(CSNK1D*,-EGFP)816Yfu
Transgene Detail

Summary

• Symbol: Tg(CSNK1D*,-EGFP)816Yfu
• Name: transgene insertion 816, Ying-Hui Fu
• MGI ID: MGI:3837569
• Synonyms: hCKIdelta-T44A L, Tg(CSNK1D*)816Yfu
• Transgene: Tg(CSNK1D*,-EGFP)816Yfu Location: unknown
• Alliance: Tg(CSNK1D*,-EGFP)816Yfu page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CSNK1D*,-EGFP)816Yfu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CSNK1D (1453)

  Csnk1d

  (MGI:1355272)

• Mutation details: The human BAC clone RP11-1376P16 containing the CSNK1D gene was targeted to generate a threonine-to-alanine mutation at amino acid 44 in the protein (T44A). An IRES-GFP cassette was also inserted after the stop codon of the CSNK1D gene. Six lines were generated with 4 of the lines 498, 503, 816 and 830, being low expressers due to insertion of only one copy of the transgene. Transgene expression was confirmed by RT-PCR of brain lysates. This is a representative record for the four low expressing lines. (J:97658)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97658 Xu Y, et al., Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31;434(7033):640-4
• All: 1 reference(s)