Tg(MMTV-AURKA)#Cxd
Transgene Detail
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Symbol: |
Tg(MMTV-AURKA)#Cxd |
Name: |
transgene insertion, Chu-Xia Deng |
MGI ID: |
MGI:3836060 |
Synonyms: |
MMTV-Aurora-A |
Transgene: |
Tg(MMTV-AURKA)#Cxd Location: unknown
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Alliance: |
Tg(MMTV-AURKA)#Cxd page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(MMTV-AURKA)#Cxd expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
AURKA (6790) |
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Mutation details: The coding sequence for the human AURKA gene (Aurora-A) was placed under the control of the mouse mammary tumor virus enhancer and promoter. Six founder lines were established using the transgene construct with the two highest expressing lines pooled for phenotypic analysis. Transgene expression for both lines was highestin the mammary and salivary glands, followed by (in descending order of expression) kidney, spleen, liver, brain, and uterus.
(J:145680)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:145680 Wang X, et al., Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene. 2006 Nov 16;25(54):7148-58 |
All: |
1 reference(s) |
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