Tg(ACTB-Lama5*G2/LAMA1)1Jhm
Transgene Detail

Summary

• Symbol: Tg(ACTB-Lama5*G2/LAMA1)1Jhm
• Name: transgene insertion 1, Jeffrey H Miner
• MGI ID: MGI:3828060
• Synonyms: Mr5G2, Mr5G2L
• Transgene: Tg(ACTB-Lama5*G2/LAMA1)1Jhm Location: unknown
• Alliance: Tg(ACTB-Lama5*G2/LAMA1)1Jhm page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-Lama5*G2/LAMA1)1Jhm expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LAMA1 (284217)

  Lama1

  (MGI:99892)

  mouse

  Lama5 (MGI:105382)
• Mutation details: The chicken beta-actin promoter with the Rous sarcoma virus-long terminal repeat from the miw vector was used to drive ubiquitous expression of a fusion gene encoding the laminin alpha chain and first 2 laminin-type globular (LG) modules from Lama5 and LG modules 3-5 of human LAMA1. Two lines were created and line 1 represents the low expressor. (J:118788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:118788 Kikkawa Y, et al., Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. J Biol Chem. 2002 Nov 22;277(47):44864-9
• All: 2 reference(s)