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Xlch Gene Detail
Summary
  • Symbol
    Xlch
  • Name
    X-linked cardiac hypertrophy
  • Synonyms
    Family 78, Hlb545
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:3797603
Location & Maps
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  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome X, Syntenic
Human Diseases
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  • Diseases
    1 with Xlch mouse models

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 3b; CMD3B   OMIM: 302045 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Chemically induced (ENU)
    1
Heterozygotes for this ENU-induced mutation exhibit cardiac hypertrophy and partial lethality at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
References
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  • Summaries
    All 2
    Diseases 1
    Gene Ontology 1
    Phenotypes 1
  • Earliest
    J:136798 Leatherbury L, et al., A novel mouse model of X-linked cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2701-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory