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Tg(Myh6-TNNT2*I79N)8Jdp
Transgene Detail
Summary
Symbol: Tg(Myh6-TNNT2*I79N)8Jdp
Name: transgene insertion 8, James D Potter
MGI ID: MGI:3793476
Synonyms: HCTnT-I79N, Tg-I79N
Transgene: Tg(Myh6-TNNT2*I79N)8Jdp  Location: unknown  
Alliance: Tg(Myh6-TNNT2*I79N)8Jdp page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-TNNT2*I79N)8Jdp expresses 1 gene
 
Mutation detailsThe transgene construct consists of about 5.5 kilobases of the mouse alpha-myosin heavy chain promoter, including the first 2 exons and part of the third, followed by the human TNNT2 cDNA (876 base pairs) modified to express a I79N mutation, and a 630-base pair 3'-untranslated region from the human growth hormone transcript. (J:67284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:67284 Miller T, et al., Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem. 2001 Feb 9;276(6):3743-55
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory