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Mirc1 Complex/Cluster/Region Detail
Summary
  • Symbol
    Mirc1
  • Name
    microRNA cluster 1, including Mir17 through Mir92-1
  • Synonyms
    miR-17~92, miR-17-92, Mir17-92, Mirn17-92
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:3790484
  • Cluster Members
    Mir17, Mir18, Mir19a ... (6 members)
Location & Maps
more
  • Genetic Map
    Chromosome 14, Syntenic
  • Mapping Data
    1 experiment
Human Diseases
more
  • Diseases
    1 with Mirc1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 9 alleles in 12 genetic backgrounds
    18 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this Mirn cluster results in neonatal lethality. Lung hypoplasia is observed in late gestation and newborn mice; fetal and adult B cell development are compromised also.
Expression
less
  • Literature Summary
Polymorphisms
less
  • SNPs within 2kb
    5 from dbSNP Build 142
Other Database
Links
References
more
  • Summaries
    All 50
    Developmental Gene Expression 3
    Diseases 1
    Phenotypes 42
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:240083 Wang Y, et al., HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-beta Signaling Regulation. Dev Cell. 2016 Feb 08;36(3):303-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory