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Mirc1
Complex/Cluster/Region Detail
 Symbol
Name
ID
Mirc1
microRNA cluster 1, including Mir17 through Mir92-1
MGI:3790484
Synonyms miR-17~92, miR-17-92, Mir17-92, Mirn17-92
Feature Type complex/cluster/region
Genetic Map
Chromosome 14
Syntenic

Mapping data(1)
Sequence Map
Chr14:115043671-115044506 bp
From MGI annotation of GRCm38

  836 bp   ±  kb flank

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Mouse Genome Browser
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Homozygous deletion of this Mirn cluster results in neonatal lethality. Lung hypoplasia is observed in late gestation and newborn mice; fetal and adult B cell development are compromised also.
 
Human Diseases Modeled Using Mouse Mirc1 (1)    Alleles Annotated to Human Diseases(1)   
Expression
Literature Summary: (3 records)
Other database
links
miRBaseMI0000567, MI0000568, MI0000687, MI0000688, MI0000718, MI0000719
Polymorphisms SNPs within 2kb(5 from dbSNP Build 137)
References (Earliest) J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
(Latest) J:206525 Murphy BL, et al., Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. Cancer Res. 2013 Dec 1;73(23):7068-78
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory