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Tg(ACTB-SOD2)66Ysh
Transgene Detail
Summary
Symbol: Tg(ACTB-SOD2)66Ysh
Name: transgene insertion 66, Ye-Shih Ho
MGI ID: MGI:3783732
Synonyms: MnSOD-Tg, TgHMS66, Tg(HMS)66
Transgene: Tg(ACTB-SOD2)66Ysh  Location: unknown  
Alliance: Tg(ACTB-SOD2)66Ysh page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTB-SOD2)66Ysh expresses 1 gene
 
Mutation detailscDNA for human mitochondrial superoxide dismutase (MnSOD or SOD2) was placed downstream of a human beta actin promoter and a 5' flanking sequence. The construct contained intron 1 sequence of the human beta actin gene to allow RNA splicing to occur. Line 66 was established. RNA blot analysis showed a 1.4 kb human MnSOD mRNA expressed in the mouse heart. Enzymatic activity in the heart is increased 325% relative to wild-type. (J:127776)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127776 Chen Z, et al., Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol. 1998 Nov;30(11):2281-9
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory