Tg(ACTB-SOD2)66Ysh
Transgene Detail
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Symbol: |
Tg(ACTB-SOD2)66Ysh |
Name: |
transgene insertion 66, Ye-Shih Ho |
MGI ID: |
MGI:3783732 |
Synonyms: |
MnSOD-Tg, TgHMS66, Tg(HMS)66 |
Transgene: |
Tg(ACTB-SOD2)66Ysh Location: unknown
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Alliance: |
Tg(ACTB-SOD2)66Ysh page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(ACTB-SOD2)66Ysh expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SOD2 (6648) |
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Mutation details: cDNA for human mitochondrial superoxide dismutase (MnSOD or SOD2) was placed downstream of a human beta actin promoter and a 5' flanking sequence. The construct contained intron 1 sequence of the human beta actin gene to allow RNA splicing to occur. Line 66 was established. RNA blot analysis showed a 1.4 kb human MnSOD mRNA expressed in the mouse heart. Enzymatic activity in the heart is increased 325% relative to wild-type.
(J:127776)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:127776 Chen Z, et al., Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol. 1998 Nov;30(11):2281-9 |
All: |
15 reference(s) |
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