Tg(Prnp-MAPT*P301S)PS19Vle
Transgene Detail
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Symbol: |
Tg(Prnp-MAPT*P301S)PS19Vle |
Name: |
transgene insertion PS19, Virginia M Y Lee |
MGI ID: |
MGI:3768407 |
Synonyms: |
P301S tau (line PS19), PS19 Tg |
Transgene: |
Tg(Prnp-MAPT*P301S)PS19Vle Location: Chr3:140060041-140309044 bp Genetic Position: Chr3, Syntenic
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Alliance: |
Tg(Prnp-MAPT*P301S)PS19Vle page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intergenic deletion
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Tg(Prnp-MAPT*P301S)PS19Vle expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MAPT (4137) |
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Mutation details: The transgene construct contains the P301S mutant human microtubule-associated protein tau, MAPT, under the direction of the mouse prion protein, Prnp, promoter. The expression of the mutant human MAPT is 5-fold higher than the expression of the endogenous mouse Mapt protein. Transgene insertion occurred on Chr 3, causing a 249 Kb deletion.
(J:119741)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:119741 Yoshiyama Y, et al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53(3):337-51 |
All: |
195 reference(s) |
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