Tg(APOE_i2*R158C)1Lmh
Transgene Detail
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Symbol: |
Tg(APOE_i2*R158C)1Lmh |
Name: |
transgene insertion 1, Louis M Havekes |
MGI ID: |
MGI:3768070 |
Synonyms: |
ApoE2(Arg158-Cys), Tg(APOE*2)1Lmh |
Transgene: |
Tg(APOE_i2*R158C)1Lmh Location: unknown
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Alliance: |
Tg(APOE_i2*R158C)1Lmh page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APOE_i2*R158C)1Lmh expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APOE (348) |
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Mutation details: A construct carrying an 11-kB genomic fragment containing the human APOE*2 gene and endogenous promoter, and the intergenic region between APOCl and the APOCl pseudogene, harboring the postulated liver regulatory element (HCR, hepatic control region), was used to create transgenic mice. The human APOE*2 mutation is characterized by a Arg158Cys amino acid substitution. Northern blotting analysis indicates that this transgene is expressed in the liver.
(J:37473)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:37473 van Vlijmen BJ, et al., In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice. J Biol Chem. 1996 Nov 29;271(48):30595-602 |
All: |
5 reference(s) |
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