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Tg(Th-SNCA*)1.2Ccs
Transgene Detail
Summary
Symbol: Tg(Th-SNCA*)1.2Ccs
Name: transgene insertion 1.2, Christine C Stichel
MGI ID: MGI:3764815
Synonyms: msTH, THsyn
Transgene: Tg(Th-SNCA*)1.2Ccs  Location: unknown  
Alliance: Tg(Th-SNCA*)1.2Ccs page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Th-SNCA*)1.2Ccs expresses 1 gene
 
Tg(Th-SNCA*)1.2Ccs expression driven by 1 gene
 
Mutation detailsThis transgene contains a double mutant human SNCA with amino acid substitutions of proline for alanine at position 30 (A30P) and threonine for alanine at position 53 (A53T) under the control of a mouse tyrosine hydroxylase promoter. Expression is detected in the brain. (J:127708)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two lines were created with similar expression patterns and line 1.2 was choosen as the representative line.
References
Original:  J:127708 Maskri L, et al., Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice. Neurodegener Dis. 2004;1(6):255-65
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory